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Objective@#To investigate the effect of saw palmetto extract (SPE) on the reproductive function of rats with chronic prostatitis (CP).@*METHODS@#Forty male SD rats were equally randomized into groups A (blank control), B (blank control + SPE, C (CP model control) and D (CP model + SPE), and the CP model was made by injection of 1% λ-carrageenan solution into the prostate. The animals in groups A and C were gavaged with normal saline while those in groups B and D with SPE at 0.10 g/kg/d, all for 30 successive days. After drug withdrawal, the rats were mated with female ones in the ratio of 1∶1) and sacrificed 7 days later, their bilateral epididymides collected for detection of sperm count and motility. The numbers of pregnancies and fetuses were recorded and compared among different groups.@*RESULTS@#Compared with the rats in group A, those in group C showed a marked decrease in epididymal sperm motility (［68.01 ± 1.80］% vs ［62.59 ± 4.82］%, P 0.05). There were no statistically significant differences in the count of epididymal sperm, rate of pregnancy and number of fetuses between group A and the other groups (P > 0.05).@*CONCLUSIONS@#SPE can improve the semen parameters of CP rats, and has no adverse effect on the rate of pregnancy and number of fetuses.
ABSTRACT
Objective:To investigate the effect of saw palmetto extract ( SR ) on GL261 glioma in rats and immune system.Methods:The 40 rats were divided into 4 groups randomly,one was the control group without tumor( the blank group) ( n=10) ,the other 30 rats were given subcutaneous inoculation of tumor cells and then divided into 3 groups:the tumor-bearing group( n=10) ,low dose SR group( n=10) ,and high dose SR group( n=10).After 1 week fed,the rats of SR groups were given the saw palmetto extract,low dose group 50 mg/kg once a day every other day and 300 mg/kg of high dose group every other day.The tumor-bearing groups received the same dose of distilled water.After 4 weeks fed, we measured the tumor weight and the inhibition rate was calculated.The tumor cell apoptosis was detected by TUNEL staining.The activity of splenic macrophages was detected by macrophage phagocytosis of chicken erythrocytes and CD4+lymphocytes by flow cytometry.Results:①The SR groups compared with tumor group, the tumor weight was significantly reduced(F=62.678,P=0.000).The tumor inhibition rate was significantly higher in high dose group.②The apoptosis of tumor cells in tumor-bearing group was significantly less than SR groups and the apoptosis was significantly increased after treatment with SR ,especially in high dose SR group(F=1.287,P=0.000).③Compared with the blank group,the macrophage activity decreased remarkablely.SR enhanced the macrophage activity obviously, positively related to doses of SR ( F=141.205,P=0.000;F=126.903,P=0.000).④In the tumor-bearing group,the CD4+lymphocyte count decreased significantly.After SR treatment,the CD4+lymphocyte increased and were positively related to the dose of SR.Conclusion: Saw palmetto extract can strengthen the immune system.
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Objective To observe the clinical efficacy of the saw palmetto extract combined with tamsulosin for the treatment of benign prostatic hyperplasia .Methods 87 benign prostatic hyperplasia patients were randomly divided into treatment group (45 ca-ses) and control group (42 cases) .The treatment group were treated with saw palmetto extract 160mg twice a day combined with tamsulosin 20mg once a day for 8 weeks .The control group were treated with tamsulosin 20mg once a day for 8 weeks .We com-pared the residual urine volume (RU) ,maximum urinary flow rates (Qmax) ,International Prostate Symptom Score (IPSS) and vol-ume of the prostate (V) before and after the treatment .Results After 8 weeks medication ,there were significant differences of the RU ,Qmax and IPSS between before and after treatment in the control group (P0 .05) .The RU ,Qmax ,IPSS and the volume of the prostate in the treatment group were significantly changed after treatment(P<0 .05) .Conclusion Saw palmetto extract combined with tamsulosin for the treatment of benign prostatic hyper-plasia could effectively improve the patient′s symptoms ,diminish the prostate gland volume and improve the life quality of the pa-tients .